@Article{Pirayre_A_2018_j-ieee-acm-trans-comput-biol-bioinformatics_brane_ccagrnir,
  author    = {Pirayre, A. and Couprie, C. and Duval, L. and Pesquet, J.-C.},
  title     = {{BRANE} {C}lust: cluster-assisted gene regulatory network inference refinement},
  journal   = j-ieee-acm-trans-comput-biol-bioinformatics,
  year      = {2018},
  volume    = {15},
  number    = {3},
  month     = {May-Jun.},
  pages     = {850--860},
  doi       = {10.1109/TCBB.2017.2688355},
  abstract  = {Discovering meaningful   gene interactions is crucial for the identification  of novel regulatory processes in cells. Building accurately the related graphs remains challenging due to the large number of possible solutions from  available data. Nonetheless, enforcing \emph{a priori} on the graph structure, such as modularity, may reduce network indeterminacy issues. BRANE Clust (Biologically-Related A priori Network Enhancement with Clustering) refines  gene regulatory network (GRN) inference thanks to cluster information. It works as a post-processing tool for inference methods (i.e. CLR, GENIE3).  In BRANE Clust, the clustering is based on the inversion of  a system of linear equations involving a graph-Laplacian matrix promoting a modular structure. Our approach is validated on DREAM4 and DREAM5   datasets with objective measures, showing significant comparative improvements. We provide additional insights on the discovery of novel regulatory or co-expressed links  in the inferred Escherichia coli network network evaluated using the STRING database. The comparative  pertinence of clustering is discussed computationally (SIMONE, WGCNA, X-means) and biologically (RegulonDB).
BRANE Clust software is  available at: \url{http://www-syscom.univ-mlv.fr/~pirayre/Codes-GRN-BRANE-clust.html}},
  file      = {:Pirayre_A_2018_j-ieee-acm-trans-comput-biol-bioinformatics_brane_ccagrnir.pdf:PDF},
  groups    = {transcriptome, personal, 2016_j-bionformatics_brane-hk-cone},
  owner     = {duvall},
  timestamp = {2018-06-06-22-36},
}